The potential of mesenchymal stem?cell secretome for regeneration of intervertebral disc: A review article

Low back pain is a crucial public health problem that commonly associated with intervertebral disc de? generation and has vast socio?economic impact worldwide. Current treatments for degeneration are conservative, non?surgical, or surgical interventions, there no current clinical therapy aimed at directly reversing the degeneration. Given limited capacity of (IVD) cells to self?repair, treatment aiming regenerate IVDs topic interest mesenchymal stem (MSCs) have been identified as having potential in this regeneration. Recent studies revealed benefits MSC could result from molecules secrete play principal roles regulating essential biologic processes, rather than implanted themselves. Therefore, objective study review use secretome IVDs. evidence shows may by modulating gene expressions nucleus pulposus (upregulation keratin 19 downregulation matrix metalloproteinase 12 Gla protein) stimulating IVD progenitor repair degenerated disc.